In Search of Functional Advantages of Knots in Proteins

  title={In Search of Functional Advantages of Knots in Proteins},
  author={Pawel Dabrowski-Tumanski and Andrzej Stasiak and Joanna I. Sulkowska},
  booktitle={PloS one},
We analysed the structure of deeply knotted proteins representing three unrelated families of knotted proteins. We looked at the correlation between positions of knotted cores in these proteins and such local structural characteristics as the number of intra-chain contacts, structural stability and solvent accessibility. We observed that the knotted cores and especially their borders showed strong enrichment in the number of contacts. These regions showed also increased thermal stability… CONTINUE READING