In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.

@article{Hopper2016InPA,
  title={In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.},
  author={Rachel K. Hopper and Jan-Renier A. J. Moonen and Isabel Diebold and Aiqin Cao and Christopher J Rhodes and Nancy Ferreira Tojais and Jan K. Hennigs and Mingxia Gu and Lingli Wang and Marlene Rabinovitch},
  journal={Circulation},
  year={2016},
  volume={133 18},
  pages={
          1783-94
        }
}
BACKGROUND We previously reported high-throughput RNA sequencing analyses that identified heightened expression of the chromatin architectural factor High Mobility Group AT-hook 1 (HMGA1) in pulmonary arterial endothelial cells (PAECs) from patients who had idiopathic pulmonary arterial hypertension (PAH) in comparison with controls. Because HMGA1 promotes epithelial-to-mesenchymal transition in cancer, we hypothesized that increased HMGA1 could induce transition of PAECs to a smooth muscle (SM… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.

  • American journal of respiratory and critical care medicine
  • 2015
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Elafin reverses pulmonary hypertension via caveolin-1-dependent by gest on A uust 31

NP Nickel, E Spiekerkoetter, +16 authors M. Rabinovitch
  • Am J Respir Crit Care Med
  • 2017

Similar Papers