In Intact Islets Interstitial GABA Activates GABAA Receptors That Generate Tonic Currents in α-Cells

@inproceedings{Jin2013InII,
  title={In Intact Islets Interstitial GABA Activates GABAA Receptors That Generate Tonic Currents in α-Cells},
  author={Yang Jin and Sergiy V. Korol and Zhe Jin and Sebastian Barg and B Birnir},
  booktitle={PloS one},
  year={2013}
}
In the rat islets γ-aminobutyric acid (GABA) is produced by the β-cells and, at least, the α-cells express the GABA(A) receptors (GABA(A) channels). In this study, we examined in intact islets if the interstitial GABA activated the GABA(A) receptors. We used the patch-clamp technique to record whole-cell and single-channel currents and single-cell RT-PCR to identify the cell-type we recorded from, in the intact rat islets. We further identified which GABA(A) receptor subunits were expressed. We… CONTINUE READING

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