In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription

@inproceedings{Shen2010InHP,
  title={In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription},
  author={Feifei Shen and Laura Hobley and Neil Doherty and John T. Loh and Timothy L Cover and R Elizabeth Sockett and Kim Rachael Hardie and John Christopher Atherton},
  booktitle={BMC Microbiology},
  year={2010}
}
LuxS may function as a metabolic enzyme or as the synthase of a quorum sensing signalling molecule, auto-inducer-2 (AI-2); hence, the mechanism underlying phenotypic changes upon luxS inactivation is not always clear. In Helicobacter pylori, we have recently shown that, rather than functioning in recycling methionine as in most bacteria, LuxS (along with newly-characterised MccA and MccB), synthesises cysteine via reverse transsulphuration. In this study, we investigated whether and how LuxS… CONTINUE READING
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