In Egyptians, a mutation in the lymphotoxin-alpha gene may increase susceptibility to hepatitis C virus but not that to schistosomal infection.

@article{Elsammak2008InEA,
  title={In Egyptians, a mutation in the lymphotoxin-alpha gene may increase susceptibility to hepatitis C virus but not that to schistosomal infection.},
  author={Mohamed Yousry Elsammak and R M Al-Sharkaweey and Mona Ragab and G. A. M. Amin and M H Kandil},
  journal={Annals of tropical medicine and parasitology},
  year={2008},
  volume={102 8},
  pages={
          709-16
        }
}
In Egypt, human schistosomiasis is a chronic endemic disease that can produce portal hypertension and occasionally death. Curiously, most Egyptian cases of the disease are complicated by co-infection with hepatitis C virus (HCV), the co-infection generally resulting in more severe liver disease than seen in those only infected with HCV. The high frequency of co-infection may be the result of transmission of the virus during parental schistosomal therapy or schistosomiasis-related surgery but it… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Association of HLA and post-schistosomal hepatic disorder: a systematic review and meta-analysis.

  • Parasitology international
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Variants in two gene members of the TNF ligand superfamily and hepatitis C virus chronic disease

  • Gastroenterology and hepatology from bed to bench
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND & RESULTS

Neglected tropical diseases as a cause of chronic liver disease: the case of Schistosomiasis and Hepatitis C Co-infections in Egypt.

  • Liver international : official journal of the International Association for the Study of the Liver
  • 2013
VIEW 2 EXCERPTS
CITES BACKGROUND

Genes and hepatitis C: susceptibility, fibrosis progression and response to treatment.

  • Liver international : official journal of the International Association for the Study of the Liver
  • 2011
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Prospective study of viral clearance and CD4(+) T-cell response in acute hepatitis C primary infection and reinfection.

  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2006
VIEW 1 EXCERPT

Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection.

  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2005
VIEW 3 EXCERPTS

Influence of the factor

A. Tybjaerg-Hansen
  • 2005