In-Depth Analysis of the Interaction of HIV-1 with Cellular microRNA Biogenesis and Effector Mechanisms

@inproceedings{Whisnant2013InDepthAO,
  title={In-Depth Analysis of the Interaction of HIV-1 with Cellular microRNA Biogenesis and Effector Mechanisms},
  author={Adam W Whisnant and Hal P. Bogerd and Omar Zer{\'o}n Flores and Phong T. Ho and Jason G. Powers and Natalia Sharova and Mario Stevenson and Chin-ho Chen and Bryan R Cullen},
  booktitle={mBio},
  year={2013}
}
UNLABELLED The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T… CONTINUE READING
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