In Cell and In Vitro Assays to Measure PTEN Ubiquitination.

  title={In Cell and In Vitro Assays to Measure PTEN Ubiquitination.},
  author={Amit Gupta and Helene Maccario and Nisha Kriplani and Nicholas R Leslie},
  journal={Methods in molecular biology},
The lipid and protein tyrosine phosphatase, PTEN, is one of the most frequently mutated tumor suppressors in human cancers and is essential for regulating the oncogenic pro-survival PI3K/AKT signaling pathway. Because of its diverse physiological functions, PTEN has attracted great interest from researchers in multiple research fields. The functional diversity of PTEN demands a collection of delicate regulatory mechanisms, including transcriptional control and posttranslational mechanisms that… CONTINUE READING

From This Paper

Topics from this paper.
3 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…