In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients.

@article{Geisler1997InBC,
  title={In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: a cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients.},
  author={Carsten Geisler and Preben Philip and Bjarne Egelund Christensen and Klaus Hou-Jensen and Niels Thorsgaard Pedersen and Olaf Myhre Jensen and K H Thorling and Else Andersen and Henrik Sverre Birgens and Aage Drivsholm and J\orgen Ellegaard and J\orgen K. Larsen and Torben Plesner and Peter E. Brown and Per Kragh Andersen and Mogens M\ork Hansen},
  journal={Leukemia research},
  year={1997},
  volume={21 11-12},
  pages={1011-23}
}
Of 560 consecutive, newly diagnosed untreated patients with B CLL submitted for chromosome study, G-banded karyotypes could be obtained in 480 cases (86%). Of these, 345 (72%) had normal karyotypes and 135 (28%) had clonal chromosome abnormalities: trisomy 12 (+12) was found in 40 cases, 20 as +12 alone (+12single), 20 as +12 with additional abnormalities (+12complex). Other frequent findings included abnormalities of 14q, chromosome 17, 13q and 6q. The immunophenotype was typical for CLL in… CONTINUE READING