In‐vitro mutagenic potential and effect on permeability of co‐administered drugs across Caco‐2 cell monolayers of Rubus idaeus and its fortified fractions

@article{Kreander2006InvitroMP,
  title={In‐vitro mutagenic potential and effect on permeability of co‐administered drugs across Caco‐2 cell monolayers of Rubus idaeus and its fortified fractions},
  author={K. Kreander and A. Galkin and Satu Vuorela and P. Tammela and L. Laitinen and M. Heinonen and P. Vuorela},
  journal={Journal of Pharmacy and Pharmacology},
  year={2006},
  volume={58}
}
  • K. Kreander, A. Galkin, +4 authors P. Vuorela
  • Published 2006
  • Chemistry, Medicine
  • Journal of Pharmacy and Pharmacology
    • This study investigated the mutagenic, anti‐mutagenic and cytotoxic effects of acetone extract of raspberry, Rubus idaeus L. (v. Ottawa) Rosaceae, and the isolated and characterized ellagitannin and anthocyanin fractions thereof, suitable for food applications. The studied raspberry extract and fractions did not show any mutagenic effects determined in the miniaturized Ames test and were not cytotoxic to Caco‐2 cells at the used concentrations. However, the anti‐mutagenic properties were… CONTINUE READING
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    References

    SHOWING 1-10 OF 68 REFERENCES
    Antimutagenic activity of extracts of natural substances in the Salmonella/microsome assay.
    • 94
    • PDF
    In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1.
    • D. Schwarz, I. Roots
    • Chemistry, Medicine
    • Biochemical and biophysical research communications
    • 2003
    • 52
    Effects of Extracts of Commonly Consumed Food Supplements and Food Fractions on the Permeability of Drugs Across Caco-2 Cell Monolayers
    • 31
    Evaluation of the cytotoxicity, mutagenicity and antimutagenicity of emerging edible plants.
    • G. C. Yen, H. Chen, H. H. Peng
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2001
    • 125
    Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test
    • 165
    Role of monocarboxylic acid transporters in the cellular uptake of NSAIDs
    • 45
    Study of antioxidant and mutagenic activity of different orange juices
    • 64
    Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food.
    • 155
    Molecular mechanisms of toxicity of important food-borne phytotoxins.
    • 88
    Activity profiles of antimutagens: in vitro and in vivo data.
    • 81