In‐vitro and Ex‐vivo Inhibition of Blood Platelet Aggregation by Naftazone

  title={In‐vitro and Ex‐vivo Inhibition of Blood Platelet Aggregation by Naftazone},
  author={Philippe Durand and Christian Bloy and F Peltier-Pujol and Denis Blache},
  journal={Journal of Pharmacy and Pharmacology},
Because of the considerable interest in the role of platelets and antiplatelet therapy in cardiovascular disease, including the aggregation of platelets to each other during arterial thrombosis and atherogenesis, we have studied the effect of naftazone (Etioven), an original vasculotropic drug on platelet aggregation. 
Effect of naftazone on in vivo platelet function in the rat.
Results show that naftazone has similar inhibitory effects on rat platelet functions as ticloplidine, and could be a useful agent to modulate platelet function in patients with cardiovascular disease. Expand
Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative.
The results suggest that NQ12 may be a promising antithrombotic agent, and its antithromabotic activity may be due to antiplatelet aggregation activity, which may result from the inhibition of phosphoinositide breakdown and thromboxane A(2) formation. Expand
고초균에 의한 탈지대두 grits 발효물 항혈전 및 콜레스테롤 저하 효과
This study investigated antithrombotic and hypocholesterolemic activities of defatted soybean grits (DSG) and fermented DSG (FD). The FD was prepared by the solid state fermentation using BacillusExpand
Antithrombotic and Cholesterol Reduction Effects of Defatted Soybean Grits Fermented by Bacillus subtilis NUC1
This study investigated antithrombotic and hypocholesterolemic activities of defatted soybean grits (DSG) and fermented DSG (FD). The FD was prepared by the solid state fermentation using BacillusExpand
Naftazone reduces glutamate cerebro spinal fluid levels in rats and glutamate release from mouse cerebellum synaptosomes
In the present study naftazone was found to decrease glutamate levels in the cerebro spinal fluid (CSF) of rats treated for 15 days, as determined by a chemiluminescent glutamate assay reaction. Expand
Epidural hematoma after thoracic epidural analgesia in a patient treated with ketorolac, mefenamic acid, and naftazone: a case report
A 26-year-old male undergoing thoracotomy and bleeding control received a preoperative thoracic epidural for postoperative analgesia and urgent magnetic resonance imaging showed massive anterior epidural hematoma, which should be more careful to drugs with antiplatelet effect when using regional analgesia. Expand
A proof‐of‐concept, randomized, placebo‐controlled, multiple cross‐overs (n‐of‐1) study of naftazone in Parkinson’s disease
These pilot findings are consistent with preclinical data in primates and support the hypothesis that naftazone may have antiparkinsonian and antidyskinetic effects in humans that deserve further clinical investigation. Expand
Chemical constituents from Dendrobium densiflorum.
Among the identified compounds, five were found to exhibit anti-platelet aggregation activity in vitro and the structure of a previously reported compound dendroflorin obtained from the plant was revised on the basis of spectroscopic analysis. Expand
Whole Spontaneous Spinal Epidural Hematoma
A 26-year-old male who had no underlying disease, including coagulopathy, underwent thoracotomy and bleeding control due to hemothorax and was discharged without neurological deficits, becoming the first report of whole spontaneous spinal epidural hematoma in a young patient, with a history of hemorrhoid medication. Expand
Medikamentöse Behandlung chronischer Venenerkrankungen
An overview of a majority of oral preparations used so far to treat CVD including venous leg ulcers is presented, after several decades of clinical use a few flavonoid preparations collected enough evidence to recommend them as a short-term adjunct treatment of CVD. Expand


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