In‐depth molecular profiling of the biphasic components of uterine carcinosarcomas

@inproceedings{Mcconechy2015IndepthMP,
  title={In‐depth molecular profiling of the biphasic components of uterine carcinosarcomas},
  author={M. Mcconechy and Lien N Hoang and M Herman Chui and Janine Senz and Winnie Yang and Nirit M K Rozenberg and Robertson Mackenzie and Jessica N Mcalpine and David G. Huntsman and Blaise Alexander Clarke and Cyril Blake Gilks and Cheng‐Han Lee},
  booktitle={The journal of pathology. Clinical research},
  year={2015}
}
Uterine carcinosarcoma is a clinically aggressive malignancy composed of a mix of carcinomatous and sarcomatous elements. We performed targeted next-generation sequencing of 27 uterine cancer and sarcoma genes together with immunohistochemical analyses of selected proteins in 30 uterine carcinosarcomas. This included 13 cases in which the distinct carcinoma and sarcoma components were sequenced separately and 10 cases where the metastatic tumours were analysed in addition to the primary tumours… CONTINUE READING
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Highly Influential
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