In‐Vitro Activity of Miltefosine and Voriconazole on Clinical Isolates of Free‐Living Amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri

@article{Schuster2006InVitroAO,
  title={In‐Vitro Activity of Miltefosine and Voriconazole on Clinical Isolates of Free‐Living Amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri},
  author={F. Schuster and B. Guglielmo and G. Visvesvara},
  journal={Journal of Eukaryotic Microbiology},
  year={2006},
  volume={53}
}
ABSTRACT. The anticancer agent miltefosine and the antifungal drug voriconazole were tested in vitro against Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri. All three amebas are etiologic agents of chronic (Balamuthia, Acanthamoeba) or fulminant (Naegleria) encephalitides in humans and animals and, in the case of Acanthamoeba, amebic keratitis. Balamuthia exposed to <40 μm concentrations of miltefosine survived, while concentrations of ≥40 μM were generally amebacidal, with… Expand
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