In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe.

@article{Chen2017InVN,
  title={In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe.},
  author={Xiaoqiang Chen and Dayoung Lee and Sungsook Yu and Gyoungmi Kim and Songyi Lee and Yejin Cho and Haengdueng Jeong and Ki Taek Nam and Juyoung Yoon},
  journal={Biomaterials},
  year={2017},
  volume={122},
  pages={
          130-140
        }
}
The development of multifunctional reagents for simultaneous specific near-infrared (NIR) imaging and phototherapy of tumors is of great significance. This work describes the design of a cathepsin B-activated fluorescent probe (CyA-P-CyB) and its applications as an NIR imaging probe for tumor cells and as a phototherapy reagent for tumors. In vitro experiments demonstrated that CyA-P-CyB was activated via the cleavage of a peptide linker by cathepsin B in tumor cells to produce fluorescence in… CONTINUE READING
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