In vivo evidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles.

@article{Layec2014InVE,
  title={In vivo evidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles.},
  author={Gwenael Layec and Joel D. Trinity and Corey R. Hart and S. Kim and Henderik Jonathan Groot and Yann Le Fur and Jacob R. Sorensen and Eun-Kee Jeong and Russell Richardson},
  journal={Clinical science},
  year={2014},
  volume={126 8},
  pages={581-92}
}
Impaired skeletal muscle efficiency potentially contributes to the age-related decline in exercise capacity and may explain the altered haemodynamic response to exercise in the elderly. Thus we examined whether (i) the ATP cost of contraction increases with age, and (ii) this results in altered convective O(2) delivery to maintain microvascular oxygenation in the calf muscle. To this aim, we used an integrative experimental approach combining (31)P-MRS (magnetic resonance spectroscopy), Doppler… CONTINUE READING
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