In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi

@inproceedings{ONeill2015InVF,
  title={In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi},
  author={Maeghan O'Neill and James F. Geary and Dalen W. Agnew and Charles D Mackenzie and Timothy G Geary},
  booktitle={International journal for parasitology. Drugs and drug resistance},
  year={2015}
}
The use of a microfilaricidal drug for the control of onchocerciasis and lymphatic filariasis necessitates prolonged yearly dosing. Prospects for elimination or eradication of these diseases would be enhanced by availability of a macrofilaricidal drug. Flubendazole (FLBZ), a benzimidazole anthelmintic, is an appealing candidate macrofilaricide. FLBZ has demonstrated profound and potent macrofilaricidal effects in a number of experimental filarial rodent models and one human trial. Unfortunately… CONTINUE READING
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