In vitro activity of alpha-viniferin isolated from the roots of Carex humilis against Mycobacterium tuberculosis.

  title={In vitro activity of alpha-viniferin isolated from the roots of Carex humilis against Mycobacterium tuberculosis.},
  author={Hoonhee Seo and Mijung Kim and Sukyung Kim and Hafij Al Mahmud and Md Imtiazul Islam and Kung-Woo Nam and Myoung-Lae Cho and Hyun Sook Kwon and Ho-Yeon Song},
  journal={Pulmonary pharmacology \& therapeutics},
This study explores the antitubercular activity of α-viniferin, a bioactive phytochemical compound obtained from Carex humilis. α-Viniferin was active against both drug-susceptible and -resistant strains of Mycobacterium tuberculosis at MIC50s of 4.6 μM in culture broth medium and MIC50s of 2.3-4.6 μM inside macrophages and pneumocytes. In combination with streptomycin and ethambutol, α-viniferin exhibited an additive effect and partial synergy, respectively, against M. tuberculosis H37Rv… Expand
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