In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

@article{Karreth2011InVI,
  title={In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma},
  author={Florian A. Karreth and Yvonne M-S Tay and Daniele Perna and Ugo Ala and Shen Mynn Tan and Alistair G. Rust and Gina M DeNicola and Kaitlyn A. Webster and Dror Weiss and Pedro Antonio P{\'e}rez-Mancera and Michael O. Krauthammer and Ruth Halaban and Paolo Provero and David J. Adams and David A Tuveson and Pier Paolo Pandolfi},
  journal={Cell},
  year={2011},
  volume={147},
  pages={382-395}
}
We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common microRNA recognition elements (MREs). However, the functional role of ceRNAs in cancer remains unknown. Loss of PTEN, a tumor suppressor regulated by ceRNA activity, frequently occurs in melanoma. Here, we report the discovery of significant enrichment of putative PTEN ceRNAs among genes whose loss accelerates tumorigenesis following Sleeping Beauty insertional… CONTINUE READING
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