In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias.

  title={In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias.},
  author={Sergio Hernando Mu{\~n}oz and Sabela B{\'u}a and Sara Rodr{\'i}guez-Acebes and Diego Meg{\'i}as and Sagrario Ortega and Alba de Martino and Juan M{\'e}ndez},
  journal={Cell reports},
  volume={19 5},
Mammalian DNA replication origins are "licensed" by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA overreplication before cell division. CDC6 and CDT1 are highly expressed in many types of cancer cells, but the impact of their deregulated expression had not been investigated in vivo. Here, we have generated mice strains that allow the conditional… CONTINUE READING