In Vivo Cellular Reprogramming: The Next Generation

@article{Srivastava2016InVC,
  title={In Vivo Cellular Reprogramming: The Next Generation},
  author={Deepak Srivastava and Natalie DeWitt},
  journal={Cell},
  year={2016},
  volume={166},
  pages={1386-1396}
}
Cellular reprogramming technology has created new opportunities in understanding human disease, drug discovery, and regenerative medicine. While a combinatorial code was initially found to reprogram somatic cells to pluripotency, a "second generation" of cellular reprogramming involves lineage-restricted transcription factors and microRNAs that directly reprogram one somatic cell to another. This technology was enabled by gene networks active during development, which induce global shifts in… CONTINUE READING

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