Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.

Abstract

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder, a major subset of which is characterized by the accumulation of abnormal forms of the protein tau, leading to impairments in motor functions as well as language and behavioral alterations. Tau58-2/B mice express human tau with the P301S mutation found in familial forms of FTLD in… (More)
DOI: 10.1016/j.nlm.2016.01.007

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