Improving the therapeutic efficacy of peptides and proteins: a role for polysialic acids.

@article{Gregoriadis2005ImprovingTT,
  title={Improving the therapeutic efficacy of peptides and proteins: a role for polysialic acids.},
  author={Gregory Gregoriadis and Sanjay Jain and Ioannis Papaioannou and Peter Laing},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={300 1-2},
  pages={125-30}
}
Peptide and protein drugs are a growing class of therapeutics. However, their effective application in the clinic is compromised by problems, for instance proteolysis in the circulating blood, premature clearance through the kidneys, and immunogenicity. A number of approaches have been used to circumvent such shortcomings including changes in the primary peptide structure, entrapment into nanoparticles (e.g. liposomes) and conjugation to polymers. Polysialylation, namely, conjugation of… CONTINUE READING

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