Improving the patient's experience of IVF/ICSI: a proposal for an ovarian stimulation protocol with GnRH antagonist co-treatment.

@article{Devroey2009ImprovingTP,
  title={Improving the patient's experience of IVF/ICSI: a proposal for an ovarian stimulation protocol with GnRH antagonist co-treatment.},
  author={Paul Devroey and Mohamed A. Aboulghar and Juan Antonio Garc{\'i}a-Velasco and Georg Griesinger and Peter Humaidan and Efstratios M. Kolibianakis and William L. Ledger and Candido Tom{\'a}s and Bart C. J. M. Fauser},
  journal={Human reproduction},
  year={2009},
  volume={24 4},
  pages={
          764-74
        }
}
Patients undergoing IVF/ICSI frequently experience substantial treatment burden, risk and psychological distress. These three related elements contribute to a negative patient experience that can lead to treatment discontinuation if pregnancy is not achieved. One approach to minimize these factors is the use of protocols designed to achieve high term, singleton birth rates per IVF treatment started, while improving the patient's welfare. Gonadotrophin-releasing hormone (GnRH) antagonists may be… 
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Optimisation of the follicular phase in IVF/ICSI
TLDR
A series of clinical studies are presented that all revolve around the optimisation of ovarian stimulation with GnRH antagonist co-treatment, focusing on the impact of cycle day 2 progesterone levels on treatment outcome and reducing FSH consumption by substitution of FSH by low dosages of hCG during the mid-late follicular phase.
GnRH antagonist pre-treatment: one centre's experience for IVF-ICSI cycle scheduling.
[Use of GnRH antagonist for in vitro fertilization].
  • E. Ekerhovd
  • Medicine, Biology
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
  • 2011
TLDR
Stimulation with a GnRH-antagonist instead of a Gn RH-agonist in IVF, is less physically and psychologically demanding for the patients and maintains the same birth rate.
Evaluation of pretreatment with Cetrotide in an antagonist protocol for patients with PCOS undergoing IVF/ICSI cycles: a randomized clinical trial
TLDR
Women with PCOS offered early follicular phase GnRH antagonist pretreatment for three consecutive days had significantly fewer cases of OHSS and higher chemical pregnancy rates.
Is the GnRH Antagonist Protocol Effective at Preventing OHSS for Potentially High Responders Undergoing IVF/ICSI?
TLDR
It is demonstrated that for potentially high responders, the GnRHant protocol can, to some extent, lower the cancellation and incidence rates of OHSS.
Observational Study to Assess the Therapeutic Value of Four Ovarian Hyperstimulation Protocols in IVF After Pituitary Suppression with GnRH Antagonists in Normally Responding Women
TLDR
Observations support the concept that stimulation with hp-hMG could be beneficial in normal responders women undergoing pituitary suppression with GnRH antagonists, and among patients in whom two embryos with similar quality parameters (ASEBIR) were transferred, the group treated with hMG alone achieved a significantly greater clinical pregnancy rate.
A boon for infertility patients: Ovarian stimulation with GnRH antagonist
TLDR
To assess the clinical outcomes using gonadotropin-releasing hormone (GnRH) antagonist protocol in in vitro fertilization (IVF) cycles in a private practice set up in India, 510 self cycles were evaluated.
Comparison of GnRH agonist long and antagonist protocols in the same normoresponder patient undergoing assisted reproductive treatment.
TLDR
Assessment of cycle characteristics and outcomes of a group of normoresponder women who had undergone controlled ovarian hyperstimulation with both ANT and AL protocols for assisted reproductive treatment (ART) concluded that antagonists might be easily considered as the first choice in NR women undergoing ART.
Pretreatment with oral contraceptive pills to identify poor responders that may benefit from rLH supplementation during GnRH-antagonist treatment for IVF: A pilot perspective study proposal
TLDR
It is hypothesize that patients with suppressed hypothalamic-pituitary-axis activity may benefit from rLH supplementation, as GnRH-antagonist administration has the potential to induce a marked reduction in LH levels in such patients compared with that in patients that exhibit a regular recovery following the administration of oral contraceptive pills (OCPs).
Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial.
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