Improving the efficiency of stroke trials: feasibility and efficacy of group adjudication of functional end points.

Abstract

BACKGROUND AND PURPOSE Use of the modified Rankin scale (mRS) in multicenter trials may be limited by interobserver variability. We assessed the effect of this on trial power and developed a novel group adjudication approach. METHODS We generated power and sample size estimates from simulated trials modeled with varying mRS reliability. We conducted a… (More)
DOI: 10.1161/STROKEAHA.113.002266

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