Improving the chemical shift dispersion of multidimensional NMR spectra of intrinsically disordered proteins.

@article{Bermel2013ImprovingTC,
  title={Improving the chemical shift dispersion of multidimensional NMR spectra of intrinsically disordered proteins.},
  author={Wolfgang Bermel and Marta Bruix and Isabella C. Felli and V VasanthaKumarM and Roberta Pierattelli and Soraya Serrano},
  journal={Journal of biomolecular NMR},
  year={2013},
  volume={55 3},
  pages={231-7}
}
Intrinsically disordered proteins (IDPs) have recently attracted the attention of the scientific community challenging the well accepted structure-function paradigm. In the characterization of the dynamic features of proteins nuclear magnetic resonance spectroscopy (NMR) is a strategic tool of investigation. However the peculiar properties of IDPs, with the lack of a unique 3D structure and their high flexibility, have a strong impact on NMR observables (low chemical shift dispersion, efficient… CONTINUE READING