Improving the assessment of heart toxicity for all new drugs through translational regulatory science.

@article{Johannesen2014ImprovingTA,
  title={Improving the assessment of heart toxicity for all new drugs through translational regulatory science.},
  author={Lars Johannesen and Jos{\'e} Vicente and Richard A. Gray and Loriano Galeotti and Zak Loring and Christine Garnett and Jeffry A Florian and Martin Ugander and Norman L. Stockbridge and David G. Strauss},
  journal={Clinical pharmacology and therapeutics},
  year={2014},
  volume={95 5},
  pages={501-8}
}
Fourteen drugs have been removed from the market worldwide because they cause torsade de pointes. Most drugs that cause torsade can be identified by assessing whether they block the human ether à gogo related gene (hERG) potassium channel and prolong the QT interval on the electrocardiogram. In response, regulatory agencies require new drugs to undergo "thorough QT" studies. However, some drugs block hERG potassium channels and prolong QT with minimal torsade risk because they also block… CONTINUE READING
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