Improving the affinity of fibroblasts for bacterial cellulose using carbohydrate-binding modules fused to RGD.

@article{Andrade2010ImprovingTA,
  title={Improving the affinity of fibroblasts for bacterial cellulose using carbohydrate-binding modules fused to RGD.},
  author={F{\'a}bia K Andrade and Susana Margarida Gomes Moreira and Luc{\'i}lia Domingues and Francisco Miguel Gama},
  journal={Journal of biomedical materials research. Part A},
  year={2010},
  volume={92 1},
  pages={9-17}
}
The attachment of cells to biomedical materials can be improved by using adhesion sequences, such as Arg-Gly-Asp (RGD), found in several extracellular matrix proteins. In this work, bifunctional recombinant proteins, with a Cellulose-Binding Module (CBM), from the cellulosome of Clostridium thermocellum and cell binding sequences-RGD, GRGDY-were cloned and expressed in E.coli. These RGD-containing cellulose binding proteins were purified and used to coat bacterial cellulose fibres. Its effect… CONTINUE READING

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