Improving the High Variable Bioavailability of Griseofulvin by SEDDS

  title={Improving the High Variable Bioavailability of Griseofulvin by SEDDS},
  author={Adi Issam and Moawia Mohammed and AL and TABAKHA and Hantash Abdel Jalil},
  • Adi Issam, Moawia Mohammed, +2 authors Hantash Abdel Jalil
  • Published 2007
tures of oils and surfactants, ideally isotropic, and sometimes containing cosolvents, which emulsify spontaneously to produce fine oil-in-water emulsions when introduced into aqueous phase under gentle agitation. Recently, SEDDS have been formulated using medium chain triglyceride oils and nonionic surfactants, the latter being less toxic. Upon peroral administration, these systems form fine emulsions (or microemulsions) in gastro-intestinal tract (GIT) with mild agitation provided by gastric… CONTINUE READING
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