Improving the Breath-Holding CVR Measurement Using the Multiband Multi-Echo EPI Sequence

  title={Improving the Breath-Holding CVR Measurement Using the Multiband Multi-Echo EPI Sequence},
  author={Alexander D. Cohen and Amritpal S Jagra and Nicholas J. Visser and Baolian Yang and Brice Fernandez and Suchandrima Banerjee and Yang Wang},
  journal={Frontiers in Physiology},
Blood oxygen level-dependent (BOLD) functional MRI (fMRI) is commonly used to measure cerebrovascular reactivity (CVR), which can convey insightful information about neurovascular health. Breath-holding (BH) has been shown to be a practical vasodilatory stimulus for measuring CVR in clinical settings. The conventional BOLD fMRI approach has some limitations, however, such as susceptibility-induced signal dropout at air tissue interfaces and low BOLD sensitivity especially in areas of low T2… 
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