Improving study design for antidepressant effectiveness assessment.

@article{Naudet2013ImprovingSD,
  title={Improving study design for antidepressant effectiveness assessment.},
  author={Florian Naudet and Bruno Millet and Jean Michel Reymann and Bruno Falissard},
  journal={International journal of methods in psychiatric research},
  year={2013},
  volume={22 3},
  pages={
          217-31
        }
}
Antidepressants effectiveness in major depressive disorder (MDD) is still questioned because the extrapolation of randomized controlled trial (RCT) results to "real life" settings is problematic. The application of the RCT paradigm in a disorder of this type, where global care plays a central role, raises questions regarding the internal and external validity of this type of study. Outcome measurement, attrition rates, the ability of the double-blind design to control for expectations, placebo… CONTINUE READING
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