Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering.

@article{Olano2008ImprovingPO,
  title={Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering.},
  author={C. Olano and F. Lomb{\'o} and C. M{\'e}ndez and J. Salas},
  journal={Metabolic engineering},
  year={2008},
  volume={10 5},
  pages={
          281-92
        }
}
Production of secondary metabolites is a process influenced by several physico-chemical factors including nutrient supply, oxygenation, temperature and pH. These factors have been traditionally controlled and optimized in industrial fermentations in order to enhance metabolite production. In addition, traditional mutagenesis programs have been used by the pharmaceutical industry for strain and production yield improvement. In the last years, the development of recombinant DNA technology has… Expand
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