Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.

  title={Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.},
  author={Ning Tang and Gangjun Du and Nan Wang and Chunchun Liu and Haiying Hang and Wei Liang},
  journal={Journal of the National Cancer Institute},
  volume={99 13},
BACKGROUND Drug delivery and penetration into neoplastic cells distant from tumor vessels is critical for the effectiveness of solid tumor chemotherapy. We hypothesized that 10- to 20-nm nanoassemblies of phospholipids containing doxorubicin would improve the drug's penetration, accumulation, and antitumor activity. METHODS Doxorubicin was incorporated into polyethylene glycol-phosphatidylethanolamine (PEG-PE) block copolymer micelles by a self-assembly procedure to form nanoassemblies of… CONTINUE READING


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