Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial


Background:Breast cancer becomes lethal when visceral metastases develop. At this stage, anti-cancer treatments aim at relieving symptoms and delaying death without resulting in additional toxicity. On the basis of their differential anti-oxidant defence level, tumour cells can be made more sensitive to chemotherapy than non-tumour cells when membrane lipids are enriched with docosahexaenoic acid (DHA), a peroxidisable and oxidative-stress-inducing lipid of marine origin.Methods:This open-label single-arm phase II study evaluated the safety and efficacy (response rate), as primary end points, of the addition of 1.8 g DHA daily to an anthracycline-based chemotherapy (FEC) regimen in breast cancer patients (n=25) with rapidly progressing visceral metastases. The secondary end points were time to progression (TTP) and overall survival (OS).Results:The objective response rate was 44%. With a mean follow-up time of 31 months (range 2–96 months), the median TTP was 6 months. Median OS was 22 months and reached 34 months in the sub-population of patients (n=12) with the highest plasma DHA incorporation. The most common grade 3 or 4 toxicity was neutropaenia (80%).Conclusion:DHA during chemotherapy was devoid of adverse side effects and can improve the outcome of chemotherapy when highly incorporated. DHA has a potential to specifically chemosensitise tumours.

DOI: 10.1038/sj.bjc.6605441

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@article{Bougnoux2009ImprovingOO, title={Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial}, author={Philippe Bougnoux and Naoufel Hajjaji and M N Ferrasson and B. Giraudeau and Charles Couet and Olivier le Floch}, journal={British Journal of Cancer}, year={2009}, volume={101}, pages={1978 - 1985} }