Improving lycopene production in Escherichia coli by engineering metabolic control

  title={Improving lycopene production in Escherichia coli by engineering metabolic control},
  author={William R. Farmer and James C. Liao},
  journal={Nature Biotechnology},
Metabolic engineering has achieved encouraging success in producing foreign metabolites in a variety of hosts. However, common strategies for engineering metabolic pathways focus on amplifying the desired enzymes and deregulating cellular controls. As a result, uncontrolled or deregulated metabolic pathways lead to metabolic imbalance and suboptimal productivity. Here we have demonstrated the second stage of metabolic engineering effort by designing and engineering a regulatory circuit to… CONTINUE READING
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