Improving linear stiffness of the cell-seeded collagen sponge constructs by varying the components of the mechanical stimulus.

@article{Nirmalanandhan2008ImprovingLS,
  title={Improving linear stiffness of the cell-seeded collagen sponge constructs by varying the components of the mechanical stimulus.},
  author={Victor Sanjit Nirmalanandhan and Jason T. Shearn and Natalia Juncosa-Melvin and Marepalli Rao and Cynthia Gooch and Abhishek Jain and Gino Bradica and David Butler},
  journal={Tissue engineering. Part A},
  year={2008},
  volume={14 11},
  pages={1883-91}
}
In vitro mechanical stimulation has been reported to induce cell alignment and increase cellular proliferation and collagen synthesis. Our group has previously reported that in vitro mechanical stimulation of tissue-engineered tendon constructs significantly increases construct stiffness and repair biomechanics after surgery. However, these studies used a single mechanical stimulation profile, the latter composed of multiple components whose individual and combined effects on construct… CONTINUE READING

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