• Materials Science, Medicine
  • Published in
    International journal of…
    2017
  • DOI:10.2147/IJN.S145988

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers

@inproceedings{Tian2017ImprovingIA,
  title={Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers},
  author={Cihui Tian and Sajid Asghar and Yifan Wu and Zhipeng Chen and Xin Jin and Lining Yin and Lin Huang and Qineng Ping and Yanyu Xiao},
  booktitle={International journal of nanomedicine},
  year={2017}
}
The expression of multiple receptors on intestinal epithelial cells enables an actively targeted carrier to significantly enhance the oral delivery of payloads. Conjugating the receptors' ligands on the surfaces of a particulate-delivery system allows site-specific targeting. Here, we used taurocholic acid (TCA) as a ligand for uptake of nanostructured lipid carriers (NLCs) mediated by a bile-acid transporter to improve oral bioavailability of curcumin (Cur). First, synthesis of TCA… CONTINUE READING
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