Improving gene annotation of complete viral genomes.

  title={Improving gene annotation of complete viral genomes.},
  author={Ryan E Mills and Michael Rozanov and Alexandre Lomsadze and Tatiana Tatusova and Mark Yu Borodovsky},
  journal={Nucleic acids research},
  volume={31 23},
Gene annotation in viruses often relies upon similarity search methods. These methods possess high specificity but some genes may be missed, either those unique to a particular genome or those highly divergent from known homologs. To identify potentially missing viral genes we have analyzed all complete viral genomes currently available in GenBank with a specialized and augmented version of the gene finding program GeneMarkS. In particular, by implementing genome-specific self-training… CONTINUE READING