Improving gas chromatographic determination of residual solvents in pharmaceuticals by the combined use of headspace solid-phase microextraction and isotopic dilution.

@article{Coran2001ImprovingGC,
  title={Improving gas chromatographic determination of residual solvents in pharmaceuticals by the combined use of headspace solid-phase microextraction and isotopic dilution.},
  author={Silvia A. Coran and Valerio Giannellini and Sandra Furlanetto and Massimo Bambagiotti-Alberti and Sergio Pinzauti},
  journal={Journal of chromatography. A},
  year={2001},
  volume={915 1-2},
  pages={209-16}
}
Cyclohexane and toluene were gas chromatographically determined via headspace solid-phase microextraction both in ketoprofen drug substance and ketoprofen capsules by a procedure relying on isotopic dilution (ID), an analytical tool derived from mass spectrometry (MS). This approach, using an internal standard method, gave mean precision and accuracy (RSD 2.56%, 2.97% and bias 0.21%, -0.99% for cyclohexane and toluene, respectively) not obtainable by the more commonly used external standard… CONTINUE READING