Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering

  title={Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering},
  author={Dieter Blancquaert and Jeroen Van Daele and Simon Strobbe and Filip Kiekens and Sergei Storozhenko and Hans De Steur and Xavier Gellynck and Willy E E Lambert and Christophe P Stove and Dominique Van Der Straeten},
  journal={Nature Biotechnology},
Biofortification of staple crops could help to alleviate micronutrient deficiencies in humans. We show that folates in stored rice grains are unstable, which reduces the potential benefits of folate biofortification. We obtain folate concentrations that are up to 150 fold higher than those of wild-type rice by complexing folate to folate-binding proteins to improve folate stability, thereby enabling long-term storage of biofortified high-folate rice grains. 
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N at ur e A m er ic a, In c. A ll rig

  • J Van Daele
  • J. Agric. Food Chem
  • 2014

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