Improving estimates of the breakpoints in genome copy number alteration profiles with confidence masks

Abstract

Chromosomal structural changes in human body known as copy number alterations (CNAs) are often associated with disease such as cancer. Therefore, accurate estimation of the CNAs using high resolution technologies is on a front line of bioinformatics and engineering. Since the Laplace distribution recently justified to represent jitter in the CNA breakpoints… (More)
DOI: 10.1016/j.bspc.2016.08.009

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