Improving efficiency of adriamycin crossing blood brain barrier by combination of thermosensitive liposomes and hyperthermia.

@article{Gong2011ImprovingEO,
  title={Improving efficiency of adriamycin crossing blood brain barrier by combination of thermosensitive liposomes and hyperthermia.},
  author={Wei Gong and Zhiyuan Wang and Nan Liu and Wen Lin and Xingping Wang and Dong Xu and Hongyu Liu and Chunying Zeng and Xiangyang Xie and Xingguo Mei and Wanliang L{\"u}},
  journal={Biological & pharmaceutical bulletin},
  year={2011},
  volume={34 7},
  pages={1058-64}
}
Adriamycin (ADM)-encapsulated thermosensitive liposomes (ts-lip-ADM) and common liposomes (lip-ADM) were developed and evaluated. The encapsulation efficiency of the two liposomes were above 99%, and the average sizes of liposomes were about 120 nm. Temperature-dependent drug release from loaded liposomes in vitro was investigated: more than 90% of loaded ADM was released from ts-lip-ADM within 30 min at 42°C, while less than 3% was released from lip-ADM at 42°C beyond 120 min. An in vitro… CONTINUE READING

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