Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines

Abstract

High-content, image-based screens enable the identification of compounds that induce cellular responses similar to those of known drugs but through different chemical structures or targets. A central challenge in designing phenotypic screens is choosing suitable imaging biomarkers. Here we present a method for systematically identifying optimal reporter… (More)
DOI: 10.1038/nbt.3419

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@inproceedings{Kang2016ImprovingDD, title={Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines}, author={Jungseog Kang and Chien-Hsiang Hsu and Qi Wu and Shanshan Liu and Adam D. Coster and Bruce A. Posner and Steven J. Altschuler and Lani F. Wu}, booktitle={Nature Biotechnology}, year={2016} }