Improving drug delivery to primary and metastatic brain tumors: strategies to overcome the blood-brain barrier.

  title={Improving drug delivery to primary and metastatic brain tumors: strategies to overcome the blood-brain barrier.},
  author={Karen E. Parrish and Jann N. Sarkaria and William F Elmquist},
  journal={Clinical pharmacology and therapeutics},
  volume={97 4},
Brain tumor diagnosis has an extremely poor prognosis, due in part to the blood-brain barrier (BBB) that prevents both early diagnosis and effective drug delivery. The infiltrative nature of primary brain tumors and the presence of micro-metastases lead to tumor cells that reside behind an intact BBB. Recent genomic technologies have identified many genetic mutations present in glioma and other central nervous system (CNS) tumors, and this information has been instrumental in guiding the… CONTINUE READING
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