Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation

@article{Hobo2012ImprovingDC,
  title={Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation},
  author={Willemijn Hobo and Tatiana I. Novobrantseva and Hanny Fredrix and Jamie Wong and Stuart Milstein and Hila Epstein-Barash and Ju Liu and Nicolaas Schaap and Robbert van der Voort and Harry Dolstra},
  journal={Cancer Immunology, Immunotherapy},
  year={2012},
  volume={62},
  pages={285-297}
}
Dendritic cell (DC)-based vaccination boosting antigen-specific immunity is being explored for the treatment of cancer and chronic viral infections. Although DC-based immunotherapy can induce immunological responses, its clinical benefit has been limited, indicating that further improvement of DC vaccine potency is essential. In this study, we explored the generation of a clinical-grade applicable DC vaccine with improved immunogenic potential by combining PD-1 ligand siRNA and target antigen… CONTINUE READING

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