Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies.

@article{Gurtner2011ImprovingCS,
  title={Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies.},
  author={Geoffrey C. Gurtner and Reinhold H. Dauskardt and Victor W. Wong and Kirit A Bhatt and Kenneth Q Wu and Ivan N. Vial and Karine Padois and Joshua M Korman and Michael Thornton Longaker},
  journal={Annals of surgery},
  year={2011},
  volume={254 2},
  pages={217-25}
}
OBJECTIVE To test the hypothesis that the mechanical environment of cutaneous wounds can control scar formation. BACKGROUND Mechanical forces have been recognized to modulate myriad biologic processes, but the role of physical force in scar formation remains unclear. Furthermore, the therapeutic benefits of offloading cutaneous wounds with a device have not been rigorously tested. METHODS A mechanomodulating polymer device was utilized to manipulate the mechanical environment of closed… CONTINUE READING