Improving bioorthogonal protein ubiquitylation by click reaction.

  title={Improving bioorthogonal protein ubiquitylation by click reaction.},
  author={Daniel Schneider and Tatjana Schneider and Daniel R{\"o}sner and Martin Scheffner and Andreas Marx},
  journal={Bioorganic & medicinal chemistry},
  volume={21 12},
Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical properties of the modified protein. To investigate the effect(s) of ubiquitylation on the properties of a protein, sufficient amounts of homogenously and well-defined ubiquitylated proteins are required. Here, we report on the elaboration of a… CONTINUE READING


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