Improving RNA-Seq Precision with MapAl

  title={Improving RNA-Seq Precision with MapAl},
  author={Paweł P Łabaj and Bryan E. Linggi and H. Steven Wiley and David P. Kreil},
  booktitle={Front. Gene.},
With currently available RNA-Seq pipelines, expression estimates for most genes are very noisy. We here introduce MapAl, a tool for RNA-Seq expression profiling that builds on the established programs Bowtie and Cufflinks. In the post-processing of RNA-Seq reads, it incorporates gene models already at the stage of read alignment, increasing the number of reliably measured known transcripts consistently by 50%. Adding genes identified de novo then allows a reliable assessment of double the total… CONTINUE READING
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Improving RNA-Seq precision with MapAl

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