Improving RNA-Seq Precision with MapAl

@inproceedings{abaj2012ImprovingRP,
  title={Improving RNA-Seq Precision with MapAl},
  author={Paweł P Łabaj and Bryan E. Linggi and H. Steven Wiley and David P. Kreil},
  booktitle={Front. Gene.},
  year={2012}
}
With currently available RNA-Seq pipelines, expression estimates for most genes are very noisy. We here introduce MapAl, a tool for RNA-Seq expression profiling that builds on the established programs Bowtie and Cufflinks. In the post-processing of RNA-Seq reads, it incorporates gene models already at the stage of read alignment, increasing the number of reliably measured known transcripts consistently by 50%. Adding genes identified de novo then allows a reliable assessment of double the total… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 3 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-2 of 2 extracted citations

Methods to study splicing from high-throughput RNA sequencing data.

Methods in molecular biology • 2014
View 7 Excerpts
Method Support
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Improving RNA-Seq precision with MapAl

PP Citation Łabaj, BE Linggi, HS Wiley, DP Kreil
Front. Gene • 2012

Integrative Genomics Viewer

Nature Biotechnology • 2011
View 1 Excerpt