Improving NMR Structures of RNA.

  title={Improving NMR Structures of RNA.},
  author={Guillermo A. Bermejo and G Marius Clore and Charles D. Schwieters},
  volume={24 5},
Here, we show that modern solution nuclear magnetic resonance (NMR) structures of RNA exhibit more steric clashes and conformational ambiguities than their crystallographic X-ray counterparts. To tackle these issues, we developed RNA-ff1, a new force field for structure calculation with Xplor-NIH. Using seven published NMR datasets, RNA-ff1 improves covalent geometry and MolProbity validation criteria for clashes and backbone conformation in most cases, relative to both the previous Xplor-NIH… CONTINUE READING
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