Improvements in solubility and stability of thalidomide upon complexation with hydroxypropyl-beta-cyclodextrin.

@article{Krenn1992ImprovementsIS,
  title={Improvements in solubility and stability of thalidomide upon complexation with hydroxypropyl-beta-cyclodextrin.},
  author={M Krenn and Michael P. Gamcsik and Georgia B. Vogelsang and O. Michael Colvin and Kam W Leong},
  journal={Journal of pharmaceutical sciences},
  year={1992},
  volume={81 7},
  pages={685-9}
}
Thalidomide is in clinical use for the treatment of graft-versus-host disease in leukemia patients after bone marrow transplant. Low levels of the drug in plasma after oral administration have made an intravenous thalidomide formulation desirable. Thalidomide, however, is sparingly soluble in aqueous solution (50 micrograms/mL) and unstable. Complexation with hydroxypropyl-beta-cyclodextrin has significantly improved the aqueous solubility and stability of thalidomide. Results obtained with… CONTINUE READING

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