Improvements in algorithms for phenotype inference: the NAT2 example.

  title={Improvements in algorithms for phenotype inference: the NAT2 example.},
  author={Silvia Selinski and Meinolf Blaszkewicz and Katja Ickstadt and Jan G. Hengstler and Klaus Golka},
  journal={Current drug metabolism},
  volume={15 2},
Numerous studies have analyzed the impact of N-acetyltransferase 2 (NAT2) polymorphisms on drug efficacy, side effects as well as cancer risk. Here, we present the state of the art of deriving haplotypes from polymorphisms and discuss the available software. PHASE v2.1 is currently considered a gold standard for NAT2 haplotype assignment. In vitro studies have shown that some slow acetylation genotypes confer reduced protein stability. This has been observed particularly for G191A, T341C and… CONTINUE READING
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