Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats.

@article{Xing2013ImprovementOV,
  title={Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats.},
  author={Wenjuan Xing and Youyou Li and Haifeng Zhang and Chunjuan Mi and Zuoxu Hou and Michael J. Quon and Feng Gao},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={305 8},
  pages={H1111-9}
}
Exercise training lowers blood pressure and is a recommended nonpharmacological strategy and useful adjunctive therapy for hypertensive patients. Studies demonstrate that physical activity attenuates progression of hypertension. However, underlying mechanisms remain elusive. Vascular insulin resistance and endothelial dysfunction plays a critical role in the development of hypertension. The present study investigated whether long-term physical exercise starting during the prehypertensive period… CONTINUE READING
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